Science News from BCVS 2017

MANF, A Structurally Unique Redox-Sensitive Chaperone, Restores ER Protein Folding in the Ischemic Heart
Adrian Arrieta | San Diego State University, San Diego, CA

• RESULTS: MANF’s function in reducing ischemic heart damage described.
• Abstract

Loss of Type 9 Adenylyl Cyclase Triggers Reduced Phosphorylation of Hsp20 and Diastolic Dysfunction
Tanya A Baldwin | McGovern Medical School at University of Texas Health Science Center at Houston (UTHealth), Houston, TX

• RESULTS: New roles for AC9 in cardiac function identified.
• Abstract

MicroRNAs Mediate the Hemodynamic Regulation of Endothelium-to-Smooth Muscle Signaling
Jing Zhou | Peking University Health Science Center, Beijing, China

• RESULTS: Identification of SNARE activation process may prove valuable for proliferative vascular diseases.
• Abstract
• Video Interview

Β-Arrestin-Biased Agonism of Β-Adrenergic Receptor Regulates Dicer-mediated MicroRNA Maturation to Promote Cardioprotective Signaling
Jian-Peng Teoh | Augusta University, Augusta, GA

• RESULTS: Novel cardioprotective mechanism described for Β-adrenergic receptor (ΒAR) signaling.
• Abstract

Sildenafil Inhibits Neointimal Hyperplasia After Angioplasty, and Reduces Platelet Aggregation
Han Mo Yang | Seoul National University Hospital, Seoul, Korea, Republic of

• RESULTS: Future applications for sildenafil results may reduce drug-eluting stent complications.
• Abstract
• AHA Press Release: Stent coated with an erectile dysfunction drug may help prevent blood clots and artery narrowing (new window)(link opens in new window)

Cardiomyocyte CaMKII Mediates Expression of Pro-inflammatory Chemokines and Cytokines, Macrophage Infiltration and Cardiac Remodeling in Response to Pressure
Takeshi Suetomi | Department of Pharmacology, University of California, San Diego, School of Medicine, La Jolla, CA

• RESULTS: CMKII's role in inflammatory response, fibrosis, and heart failure.
• Abstract

Restoration of Impaired Diastolic Function in Hypertrophic Cardiomyopathy Induced Pluripotent Stem Cell-derived Cardiomyocytes by Re-balancing the Calcium
Haodi Wu | Stanford University, Stanford, CA

• RESULTS: Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) demonstrate cellular mechanism for diastolic dysfunction.
• Abstract

Chromatin Organization in Diseased and Healthy Mouse Heart
Chukwuemeka George Anene Nzelu | National University of Singapore, Singapore, Singapore

• RESULTS: 3-D chromatin structure offers first clues to genome-wide chromatin interactions, genomic compartments, and cardiac-specific gene expression.
• Abstract

CTRP9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling
Wenjun Yan | Thomas Jefferson University, Philadelphia, PA

• RESULTS: CTRP9 is key to a healthy microenvironment; stem cell research in myocardial infarction may benefit from this finding.
• Abstract

Tracking of CD16 Monocytes Following Delivery Into the Ischemic Limb - a Bench to Bedside Study
Ashish S Patel | King's College London, London, United Kingdom

• RESULTS: First-in-man study finds CD16 monocytes viable in ischemic tissue, suggesting a potential future therapeutic option for patients with critical limb ischemia.
• Abstract

Myocardial Hypertrophy and Circulating RNAs
Ravi V Shah | Massachusetts General Hospital, Boston, MA

• RESULTS: Circulating miRNAs may provide molecular protection in the progression of myocardial hypertrophy to heart failure.
• Abstract

Searching Genetic Modifiers For bag3-based Cardiomyopathy Using Adult Zebrafish Models
Yonghe Ding | Mayo Clinic, Rochester, MN

• RESULTS: Forward mutagenesis screening strategy may help to identify genetic modifiers for cardiomyopathy.
• Abstract

Sphingosine-1-Phosphate and RhoA Signaling Regulate Dynamin-Related Protein 1 and Cardiac Mitochondrial Fission
Cameron S Brand | Univ of California San Diego, La Jolla, CA

• RESULTS: Mitochondrial fission suggests new cardioprotective pathway.
• Abstract

CD16 Monocytes Stimulate Arteriogenesis to Salvage the Ischemic Limb
Ashish S Patel | King's College London, London, United Kingdom

• RESULTS: Potential therapeutic role using tissue-remodeling monocytes expressing CD16 for critical limb ischemia patients.
• Abstract

The Success of Humanizing Miniature Hearts is the Right Cannulation
Duong T Nguyen | AstraZeneca, Molndal, Sweden

• RESULTS: Novel cannulation approach for preserving cardiac circulation may translate to humans.
• Abstract

Targeting Beta Adrenergic Receptor Resensitization Aids in Preservation of Receptor Function
Elizabeth E Martellli | Cleveland Clinic, Cleveland, OH
Presented by Sathyamangla V. Naga Prasad | Cleveland Clinic, Cleveland, OH

• RESULTS: Evidence that resensitization of beta adrenergic receptors is inhibited in heart failure suggests future therapeutic targets.
• Abstract

TAB2 is Molecular Switch That Critically Regulates Myocardial Survival and Necroptosis
Qinghang Liu | University of Washington, Seattle, WA
Presented by Xiaoyun Guo | University of Washington, Seattle, WA

• RESULTS: TAB2 found to be key regulator in myocardial cell death (necroptosis) and remodeling.
• Abstract

Cardiac Activation of β-catenin in Mice Leads to Prolongation of QRS and Susceptibility to Arrhythmia by Inhibiting Na+ Channel Activity Through Suppression of NaV1.5 Expression
Rong Huo | UCLA, Los Angeles, CA

• RESULTS: Mechanism for β-catenin’s role in arrhythmias described in pre-clinical study.
• Abstract

Two Different Microdomains of β1-adrenoreceptor Signaling Revealed by Live Cell Imaging
Alexander Froese | University Medical Center Hamburg, Hamburg, Germany

• RESULTS: Location, location – different microdomains result in different signaling for cardiomyocyte β1-adrenergic receptors.
• Abstract